Hemoglobin subunit alpha

Quality 0.50 · 3 views · Updated 2 months ago

Human hemoglobin protein

title: "Hemoglobin subunit alpha" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hemoglobins"] description: "Human hemoglobin protein" topic_path: "general/hemoglobins" source: "https://en.wikipedia.org/wiki/Hemoglobin_subunit_alpha" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Human hemoglobin protein ::

Hemoglobin subunit alpha, Hemoglobin, alpha 1, is a hemoglobin protein that in humans is encoded by the HBA1 gene.

Gene

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1; this gene) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions.

Protein

Two alpha chains plus two beta chains constitute HbA, which in normal adult life accounts for about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with fetal hemoglobin (HbF), composed of alpha and gamma chains, make up the remaining 3% of adult hemoglobin.

Clinical significance

Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.

Interactions

Hemoglobin subunit alpha has been shown to interact with hemoglobin subunit beta (HBB).

References

References

  1. "HBA1 gene: MedlinePlus Genetics".
  2. "Entrez Gene: HBA1 hemoglobin, alpha 1".
  3. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell.
  4. Shaanan B. (November 1983). "Structure of human oxyhaemoglobin at 2.1 A resolution". J. Mol. Biol..

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::

hemoglobins