GUCA1B

Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene. Alternative names:

• Guanylate cyclase activator 1B
• Retinal guanylyl cyclase activator protein p24

Guanylyl cyclase-activating protein 2 is proposed to play a role in dark adaptation. Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate guanylyl cyclase. This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.

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• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

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