Fisetin

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Plant chemical

title: "Fisetin" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["17β-hydroxysteroid-dehydrogenase-inhibitors", "flavonols", "topoisomerase-inhibitors", "catechols", "tetrols"] description: "Plant chemical" topic_path: "general/17b-hydroxysteroid-dehydrogenase-inhibitors" source: "https://en.wikipedia.org/wiki/Fisetin" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Plant chemical ::

| Watchedfields = changed | verifiedrevid = 477167329 | Name = Fisetin | ImageFile = Fisetin.svg | ImageSize = 250px | ImageAlt = Skeletal formula of fisetin | ImageFile1 = Fisetin-3D-balls.png | ImageAlt1 = Ball-and-stick model of the fisetin molecule | ImageName = Fisetin structure | IUPACName = 3,3′,4′,7-Tetrahydroxyflavone | SystematicName = 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one | OtherNames = 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxychromen-4-one Cotinin (not to be confused with Cotinine) 5-Deoxyquercetin Superfustel Fisetholz Fietin Fustel Fustet Viset Junger fustik |Section1={{Chembox Identifiers | IUPHAR_ligand = 5182 | ChemSpiderID_Ref = | ChemSpiderID = 4444933 | KEGG_Ref = | KEGG = C10041 | InChI = 1/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H | InChIKey = XHEFDIBZLJXQHF-UHFFFAOYAQ | ChEMBL_Ref = | ChEMBL = 31574 | StdInChI_Ref = | StdInChI = 1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H | StdInChIKey_Ref = | StdInChIKey = XHEFDIBZLJXQHF-UHFFFAOYSA-N | CASNo_Ref = | CASNo = 528-48-3 | UNII_Ref = | UNII = OO2ABO9578 | PubChem = 5281614 | DrugBank_Ref = | DrugBank = DB07795 | ChEBI_Ref = | ChEBI = 42567 | SMILES = O=C1c3c(O/C(=C1/O)c2ccc(O)c(O)c2)cc(O)cc3 |Section2={{Chembox Properties | Formula = C15H10O6 | MolarMass = 286.2363 g/mol | Density = 1.688 g/mL | MeltingPtC = 330 | BoilingPt = Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. It occurs in many plants where it serves as a yellow pigment. It is found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers.

Its chemical formula was first described by Austrian chemist Josef Herzig in 1891.

Sources

Fisetin is a flavonoid synthesized by many plants such as the trees and shrubs of Fabaceae, acacias Acacia greggii, and Acacia berlandieri, parrot tree (Butea frondosa), honey locust (Gleditsia triacanthos), members of the family Anacardiaceae such as the Quebracho colorado, and species of the genus Rhus, which contains the sumacs. Along with myricetin, fisetin provides the color of the traditional yellow dye young fustic, an extract from the Eurasian smoketree (Rhus cotinus).

Many fruits and vegetables contain fisetin. and teas. It is also present in Pinophyta species such as the yellow cypress (Callitropsis nootkatensis).

The average intake of fisetin from foods in Japan is about 0.4 mg per day.

::data[format=table] | Plant source | Amount of fisetin (μg/g) | |---|---| | last1=Lee | first1=Seon-Ok | last2=Kim | first2=Sung-Ji | last3=Kim | first3=Ju-Sung | last4=Ji | first4=Hyuk | last5=Lee | first5=Eun-Ok | last6=Lee | first6=Hyo-Jeong | title=Comparison of the main components and bioactivity of Rhus verniciflua Stokes extracts by different detoxification processing methods | journal=BMC Complementary and Alternative Medicine | volume=18 | date=2021-06-02 | issue=1 | pmid=30165848 | doi=10.1186/s12906-018-2310-x | page=242| pmc=6118002 | doi-access=free }} | 15000 | | Strawberry | 160 | | Apple | 26 | | Persimmon | 10.6 | | Onion | 4.8 | | Lotus root | 5.8 | | Grape | 3.9 | | Kiwifruit | 2.0 | | Peach | 0.6 | | Cucumber | 0.1 | | Tomato | 0.1 | ::

Research

Although fisetin has been under laboratory research over several decades for its potential role in senescence or anticancer properties, among other possible effects, there is no clinical evidence that it provides any benefit to human health, as of 2018.

References

References

  1. (2018-10-01). "Fisetin is a senotherapeutic that extends health and lifespan". eBioMedicine.
  2. (2000). "Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration". The Journal of Nutrition.
  3. (2011). "Directly suspended droplet microextraction with in injection-port derivatization coupled to gas chromatography–mass spectrometry for the analysis of polyphenols in herbal infusions, fruits and functional foods". Journal of Chromatography A.
  4. (2005). "Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity". The British Journal of Nutrition.
  5. (1891). "Studien über Quercetin und seine Derivate, VII. Abhandlung". Monatshefte für Chemie.
  6. Forbes TDA, Clement BA. "Chemistry of Acacia's from South Texas". Texas A&M Agricultural Research and Extension Center at.
  7. (1966). "Antibacterial Effect of Fisetin and Fisetinidin". [[Nature (journal).
  8. (2002). "Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver". International Journal of Clinical Pharmacology and Therapeutics.
  9. (2021-06-02). "Comparison of the main components and bioactivity of Rhus verniciflua Stokes extracts by different detoxification processing methods". BMC Complementary and Alternative Medicine.

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17β-hydroxysteroid-dehydrogenase-inhibitorsflavonolstopoisomerase-inhibitorscatecholstetrols