FGF15

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Mammalian protein found in Mus musculus

title: "FGF15" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["fibroblast-growth-factor", "peptide-hormones"] description: "Mammalian protein found in Mus musculus" topic_path: "arts/film" source: "https://en.wikipedia.org/wiki/FGF15" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Mammalian protein found in Mus musculus ::

::data[format=table title="Infobox nonhuman protein"]

Field	Value
Name	Fibroblast growth factor 15
Organism	Mus musculus
TaxID	10090
Symbol	Fgf15
EntrezGene	14170
HomoloGene	3754
RefSeqmRNA	NM_008003.2
RefSeqProtein	NP_032029.1
UniProt	O35622
Chromosome	7
EntrezChromosome	NC_000073.6
GenLoc_start	144896532
GenLoc_end	144900953
::

Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor (FGF) family but, like FGF19, FGF21 and FGF23, has endocrine functions. FGF19 is the orthologous protein in humans. They are often referred together as FGF15/19.

Identification

FGF15 was first described in developing mouse brain. There is no human FGF15.

Structure

The mouse Fgf15 gene is syntenic with the human FGF19 gene. FGF15 and FGF19 proteins share about 50% amino acid identity, are found in the same tissues, and have similar functions in mouse and humans.

Functions

FGF15 is found in the absorptive cells of the mouse ileum and plays an important role in feedback inhibition of hepatic bile acid synthesis. FGF15 (and FGF19 in humans) function as hormones produced in response to bile acid absorption acting on the farnesoid X receptor FXR, are secreted into the portal venous circulation and bind onto the liver membrane receptor FGFR4/β-Klotho and repress bile acid synthesis by the Cyp7a1 gene.

In a mouse model of chronic diarrhea due to bile acid malabsorption, FGF15 administration, or stimulation of its production, reduced the bile acid loss by inhibiting new synthesis.

FGF15 has effects on energy homeostasis. Fgf15-knock-out mice have reduced liver glycogen storage and are glucose-intolerant.

FGF15 has been implicated in liver regeneration and repair. Fgf15-deficient mice have impaired regeneration.

References

NCBI. "Mouse FGF15 fibroblast growth factor 15".
(2012). "Endocrine FGFS and Klothos".
(Feb 2012). "Endocrine fibroblast growth factors 15/19 and 21: from feast to famine". Genes & Development.
(Sep 1997). "A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1". Development.
(2002). "Analysis of Fgf15 expression pattern in the mouse neural tube". Brain Research Bulletin.
(Aug 2003). "Study of Fgf15 gene expression in developing mouse brain". Gene Expression Patterns.
(May 2004). "Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction". Developmental Biology.
(Oct 2005). "Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis". Cell Metabolism.
(Dec 2007). "FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption". Journal of Lipid Research.
(Mar 2011). "FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis". Science.
(Dec 2012). "Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice". Hepatology.
(May 2014). "Fibroblast growth factor 15 deficiency impairs liver regeneration in mice". American Journal of Physiology. Gastrointestinal and Liver Physiology.

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::