FAM40A

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Protein-coding gene in the species Homo sapiens

title: "FAM40A" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/FAM40A" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Protein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the FAM40A gene.

Characteristics and secondary structure

FAM40A has an isoelectric point of 5.92 and a molecular weight of 95,575 daltons. It is predicted to have three transmembrane domains, making it a transmembrane protein. FAM40A does not contain a signal peptide and is also predicted to bind to DNA, possibly making it a membrane protein in the nuclear membrane. ::figure[src="https://upload.wikimedia.org/wikipedia/commons/4/4f/Transmembrane.png" caption="Prediction of the orientation of the transmembrane domains of FAM40A"] ::

The secondary structure of FAM40A is predicted to contain twenty-six alpha helices and two beta sheets. The 5' untranslated region of FAM40A is predicted to contain one stem-loop and the 3' untranslated region is predicted to contain eight stem-loop structures. Two miRNAs are predicted to bind to two of the stem-loop structures present in the 3' UTR region.

Homology

FAM40A has no paralogs. However, it does have orthologs stretching all the way back to yeast. It has been suggested that FAM40A is a homolog to the yeast gene FAR11, which is involved in the recovery from cell cycle arrest.

The following table represents a small selection of orthologs found using searches in BLAST and BLAT. This is by no means a comprehensive list, however it does show the vast diversity of species where FAM40A orthologs are found.

::data[format=table]

Scientific nameCommon nameAccession number (from NCBI )Sequence lengthPercent identityPercent Similarity
Homo sapiensHumanNP_149079837--
Pongo abeliiSumatran orangutanXP_00281052083799.6%100%
Sus scrofaPigXP_00312590483798.8%100%
Equus caballusHorseXP_00149376283798.8%100%
Mus musculusMouseNP_70579183798%100%
Rattus norvegicusRatXP_00106828883797.8%100%
Monodelphis domesticaGray short-tailed opossumXP_00137258884395.4%100%
Danio rerioZebra fishXP_00191892981383.4%98%
Canis lupus familiarisDogFrom BLAT81296.1%100%
Ailuropoda melanoleucaPandaFrom BLAT823$96.2100%
Oryzias latipesMedakaFrom BLAT75178.4%96%
Xenopus (Silurana) tropicalisWestern clawed frogNP_00102748381986.4%96%
Aedes aegyptiYellow-fever mosquitoXP_00165869282951.2%97%
Tribolium castaneumRed flour beetleXP_00181516481757.4%97%
Hydra magnipapillataHydra hydrozoanXP_00216486683044%97%
Ciona intestinalisSea squirtXP_00213055886746.4%97%
Pediculus humanus corporisHuman liceXP_00242596480852.7%97%
Nasonia vitripennisJewel waspXP_00160385980252.7%97%
Drosophila erectaFruit flyXP_00197174388245.2%97%
Saccharomyces cerevisiaeBakers yeastNP_01427295318.9%97%
::

Expression

FAM40A is expressed in high levels during the blastocyst, eight-cell stage, and fetal stages of development. FAM40A has also been shown to be expressed in high levels in the mammary glands, brain, thymus, mouth and the testes. It has also been shown to be expressed in high levels in mammary gland tumors, leukemia cells, and germ cell tumors.

::figure[src="https://upload.wikimedia.org/wikipedia/commons/c/c0/Expression_data.png" caption="Predicted FAM40A expression in different tissues of the body"] ::

Transcription Regulation

FAM40A is predicted to have a promoter region 789 base pairs upstream of the start of transcription. The SOX transcription factors are predicted to bind to the promoter region of the FAM40A gene, possibly indicating a role in sex determination.

Interactions

FAM40A has been shown to interact with RP6-213H19.1, STRN, and PPP2CA.

References

References

  1. (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res.
  2. (Feb 2003). "Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae". Mol Cell Biol.
  3. "Entrez Gene: FAM40A family with sequence similarity 40, member A".
  4. [http://ca.expasy.org/tools/pi_tool.html pI/MW Tool]
  5. [https://web.archive.org/web/20040320214259/http://bp.nuap.nagoya-u.ac.jp/sosui/sosui_submit.html Transmembrane domain prediction]
  6. [http://www.cbs.dtu.dk/services/SignalP/ SignalP 3.0 Server]
  7. [https://web.archive.org/web/20040320214259/http://bp.nuap.nagoya-u.ac.jp/sosui/sosui_submit.html SOSUI System]
  8. [http://www.sbg,bio.ic.ac.uk Phyre v. 2.0]{{Dead link. (April 2019)
  9. "RNA Folding Form".
  10. [http://www.mirbase.org miRBase]
  11. [https://www.yeastgenome.org/locus/FAR11 Yeast Gene FAR11 from Saccharomyces Genome Database]
  12. [https://www.ncbi.nlm.nih.gov/protein/56790935?from=1&to=837&report=gpwithparts National Center for Biotechnology Information (NCBI) Protein]
  13. [https://blast.ncbi.nlm.nih.gov/Blast.cgi NCBI BLAST: Basic Local Alignment Search Tool]
  14. [http://genome.brc.mcw.edu/cgi-bin/hgBlat BLAT Search Genome]{{dead link. (September 2017)
  15. [https://archive.today/20121222223443/http://www.ebi.ac.uk/s4/eyeresult/?node=expression&species=Homo_sapiens&term=FAM40A&tid=nameOrgENSMUSG00000014601 European Bioinformatics Institute]
  16. [https://archive.today/20121212122147/http://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.584996 EST Profile for FAM40A]
  17. "Genomatix".
  18. Goudreault, Marilyn. (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics.
  19. Ewing, Rob M. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol..

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