FABP7

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Protein-coding gene in the species Homo sapiens

title: "FABP7" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["biology-of-bipolar-disorder"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "science/biology" source: "https://en.wikipedia.org/wiki/FABP7" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.

Function

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.

FABP7 is expressed, during development, in radial glia by the activation of Notch receptors.

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-- Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.

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According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.

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::figure[src="https://upload.wikimedia.org/wikipedia/commons/4/4a/Fabp7expression.jpg" caption="Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and [[radial glia]], where [[neurogenesis]] is prominent."] ::

Role in pathology

FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.

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As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,

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-- with one, that tested for only one SNP, showing negative

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-- and another, with seven SNPs,

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-- a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.

References

References

  1. "Entrez Gene: FABP7 fatty acid binding protein 7, brain".
  2. (May 2005). "Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells". Genes & Development.
  3. (July 2008). "Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1". BMC Developmental Biology.
  4. (Oct 1996). "Ligand specificity of brain lipid-binding protein". The Journal of Biological Chemistry.
  5. (Jul 2003). "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia". American Journal of Human Genetics.
  6. [https://archive.today/20130415183044/http://www.schizophreniaforum.org/res/sczgene/geneoverview.asp?geneID=594 Gene Overview of All Published Schizophrenia-Association Studies for FABP7] - SZGene database at Schizophrenia Research Forum website.
  7. (Nov 2008). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia". Molecular Psychiatry.
  8. (Nov 2007). "Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype". PLOS Biology.

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biology-of-bipolar-disorder