Excisionase
title: "Excisionase" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["protein-domains"] topic_path: "general/protein-domains" source: "https://en.wikipedia.org/wiki/Excisionase" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::data[format=table title="Infobox protein family"]
| Field | Value |
|---|---|
| Symbol | Exc |
| Name | Excisionase-like protein |
| image | PDB 2og0 EBI.jpg |
| caption | crystal structure of the lambda xis-dna complex |
| Pfam | PF07825 |
| Pfam_clan | CL0123 |
| InterPro | IPR012884 |
| :: |
| Symbol = Exc | Name = Excisionase-like protein | image = PDB 2og0 EBI.jpg | width = | caption = crystal structure of the lambda xis-dna complex | Pfam = PF07825 | Pfam_clan = CL0123 | InterPro = IPR012884 | SMART = | PROSITE = | MEROPS = | SCOP = | OPM family = | OPM protein = | CAZy = | CDD = In molecular biology, excisionase is a bacteriophage protein encoded by the Xis gene. It is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual winged-helix structure in which two alpha helices are packed against two extended strands. Also present in the structure is a two-stranded anti-parallel beta-sheet, whose strands are connected by a four-residue wing. During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of excisionase is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal alpha helix may fold upon interaction with Int and/or DNA.
References
References
- (December 2002). "Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein". J. Mol. Biol..
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