Ecdysteroid

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Group of steroid hormones

title: "Ecdysteroid" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["steroids", "insect-hormones"] description: "Group of steroid hormones" topic_path: "general/steroids" source: "https://en.wikipedia.org/wiki/Ecdysteroid" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Group of steroid hormones ::

::figure[src="https://upload.wikimedia.org/wikipedia/commons/5/56/Ecdysteroids.svg" caption="Chemical structures of ecdysteroids, [[ecdysone]] (top) and [[20-hydroxyecdysone"] ::

Ecdysteroids are arthropod steroid hormones that are mainly responsible for molting (ecdysis), development and, to a lesser extent, reproduction; examples of ecdysteroids include ecdysone, 20-hydroxyecdysone (ecdysterone), turkesterone and 2-deoxyecdysone. These compounds are synthesized in arthropods from dietary cholesterol via the Halloween family of cytochrome P450 enzymes.

Compounds with ecdysteroid activity in arthropods are not only produced by these animals (zooecdysteroids). Phytoecdysteroids also appear in many plants mostly as a protection agents (toxins or antifeedants) against herbivore insects. Fungi also produce a handful of mycoecdysteroids. In addition, synthetic ecdysteroid pesticides such as methoxyfenozide have been produced.

Mammals

Ecdysterone has been tested on mammals due to the interest in its potential hypertrophic effect. It has been found to increase hypertrophy in rats at a similar level to some anabolic androgenic steroids and SARMs. This is proposed to be through increase of Calcium leading to activation of Akt and protein synthesis in skeletal muscles. A newer study points to estrogen receptor beta.

20-hydroxyecdysone is a human drug candidate.

References

References

  1. (2006). "Ecdysteroids: the overlooked sex steroids of insects? Males: the black box". Insect Science.
  2. (December 1970). "Control of molting in mandibulate and chelicerate arthropods by ecdysones". The Biological Bulletin.
  3. (June 2006). "Ecdysteroid titers and developmental expression of ecdysteroid-regulated genes during metamorphosis of the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae)". Journal of Insect Physiology.
  4. (2023). "Steroid hormone signaling: What we can learn from insect models". Elsevier.
  5. "Ecdysteroids Information". [[Examine.com]].
  6. (November 2011). "Ecdysteroid metabolism in crustaceans". The Journal of Steroid Biochemistry and Molecular Biology.
  7. (June 2001). "Phytoecdysteroids: biological aspects". Phytochemistry.
  8. (July 2001). "On the distribution of phytoecdysteroids in plants". Cellular and Molecular Life Sciences.
  9. (2020). "Handbook of Dietary Phytochemicals".
  10. (February 2001). "The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist.". Pest Management Science.
  11. (June 2015). "Ecdysteroids: A novel class of anabolic agents?". Biology of Sport.
  12. (October 2010). "Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells". Steroids.
  13. (September 2014). "Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone". Molecular Nutrition & Food Research.
  14. Sharma, Soumya. (2024-07-12). "FDA approves Biophytis' Phase II OBA obesity study".

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steroidsinsect-hormones