Dopastin

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title: "Dopastin" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["nitrosamines", "dopamine-beta-hydroxylase-inhibitors", "hydroxylamines"] topic_path: "general/nitrosamines" source: "https://en.wikipedia.org/wiki/Dopastin" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

| ImageFile = Dopastin.svg | ImageSize = | PIN = (2E)-N-{(2S)-2-[Hydroxy(nitroso)amino]-3-methylbutyl}but-2-enamide | OtherNames = |Section1={{Chembox Identifiers | CASNo = 37134-80-8 | CASNo_Ref = | UNII_Ref = | UNII = F8KR5E0EHC | PubChem = 6434226 | ChemSpiderID = 4939169 | SMILES = O=C(NCC@@HC(C)C)/C=C/C | InChI = 1/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1 | InChIKey = FJUBKTNNXRFHFD-WTSVBCDHBR | StdInChI = 1S/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1 | StdInChIKey = FJUBKTNNXRFHFD-WTSVBCDHSA-N |Section2={{Chembox Properties | C=9 | H=17 | N=3 | O=3 | Appearance = | Density = | MeltingPtC = 116 to 119 | MeltingPt_ref = | BoilingPt = | Solubility = | pKa = 5.1 |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt =

Dopastin is a chemical compound produced by the bacteria Pseudomonas No. BAC-125. It was first isolated and characterized in 1972. It is an inhibitor of the enzyme dopamine β-hydroxylase.

Dopastin can be prepared synthetically from L-valinol.

References

References

  1. ''[[Merck Index]]'', 11th Edition, '''3417'''
  2. (1972). "Dopastin, an inhibitor of dopamine -hydroxylase". The Journal of Antibiotics.
  3. (1974). "Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase". Agric. Biol. Chem..
  4. (1973). "Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin". Journal of the Chemical Society, Chemical Communications.

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nitrosaminesdopamine-beta-hydroxylase-inhibitorshydroxylamines