DEP domain
title: "DEP domain" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["protein-domains"] topic_path: "general/protein-domains" source: "https://en.wikipedia.org/wiki/DEP_domain" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::data[format=table title="Infobox protein family"]
| Field | Value |
|---|---|
| Symbol | DEP |
| Name | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) |
| image | PDB 1fsh EBI.jpg |
| caption | structural basis of the recognition of the dishevelled dep domain in the wnt signaling pathway |
| Pfam | PF00610 |
| InterPro | IPR000591 |
| CDD | cd04371 |
| :: |
| Symbol = DEP | Name = Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) | image = PDB 1fsh EBI.jpg | width = | caption = structural basis of the recognition of the dishevelled dep domain in the wnt signaling pathway | Pfam = PF00610 | Pfam_clan = | InterPro = IPR000591 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = cd04371 In molecular biology, the DEP domain (Dishevelled, Egl-10 and Pleckstrin domain) is a globular protein domain of about 80 amino acids that is found in over 50 proteins involved in G-protein signalling pathways. It was named after the three proteins it was initially found in:
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Dishevelled (Dsh and Dvl), which plays a key role in the transduction of the Wg/Wnt signal from the cell surface to the nucleus; it is a segment polarity protein required to establish coherent arrays of polarised cells and segments in embryos, and plays a role in wingless signalling.
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Egl-10, which regulates G-protein signalling in the central nervous system in RGS9.{{Cite journal | last1 = Masuho | first1 = I. | last2 = Wakasugi-Masuho | first2 = H. | last3 = Posokhova | first3 = E. N. | last4 = Patton | first4 = J. R. | last5 = Martemyanov | first5 = K. A. | title = Type 5 G Protein Subunit (G 5) Controls the Interaction of Regulator of G Protein Signaling 9 (RGS9) with Membrane Anchors | doi = 10.1074/jbc.M111.241513 | journal = Journal of Biological Chemistry | volume = 286 | issue = 24 | pages = 21806–21813 | year = 2011 | doi-access = free | pmid = 21511947 | pmc =3122235
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Pleckstrin, the major substrate of protein kinase C in platelets; Pleckstrin contains two PH domains flanking the DEP domain.
Mammalian regulators of G-protein signalling also contain these domains, and regulate signal transduction by increasing the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form. It has been proposed that the DEP domain could play a selective role in targeting DEP domain-containing proteins to specific subcellular membranous sites, perhaps even to specific G protein-coupled signaling pathways. Nuclear magnetic resonance spectroscopy has revealed that the DEP domain comprises a three-helix bundle, a beta-hairpin 'arm' composed of two beta-strands and two short beta-strands in the C-terminal region.
References
References
- Burchett SA. (October 2000). "Regulators of G protein signaling: a bestiary of modular protein binding domains". J. Neurochem..
- (December 2000). "Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway". Nat. Struct. Biol..
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