DAB2

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Human protein and coding gene

title: "DAB2" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Human protein and coding gene" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/DAB2" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Human protein and coding gene ::

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.

Function

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).

Interactions

DAB2 has been shown to interact with:

C-src tyrosine kinase,
Cdk1,
DAB2IP,
DVL2,
DVL3,
LRP2,
MYO6,
Mothers against decapentaplegic homolog 2,
Mothers against decapentaplegic homolog 3
PIN1, and
Src.

References

(January 1997). "Sequence, genomic structure, and chromosomal assignment of human DOC-2". Genomics.
(June 1998). "DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer". Oncogene.
"Entrez Gene: DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)".
(February 2003). "Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer". J. Biol. Chem..
(July 2003). "Cell cycle-dependent phosphorylation of Disabled-2 by cdc2". Oncogene.
(April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem..
(June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J..
(May 2000). "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin". Biochem. J..
(May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic.
(March 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun..
(June 2001). "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway". EMBO J..

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