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Δ4-Tibolone
δ4-Tibolone (developmental code ORG-OM-38; also known as isotibolone, 7α-methylnorethisterone, or 7α-methyl-17α-ethynyl-19-nortestosterone) is a synthetic androgen and progestin which was never marketed. The compound is a major active metabolite of tibolone, which itself is a prodrug of δ4-tibolone along with 3α-hydroxytibolone and 3β-hydroxytibolone (which, in contrast to δ4-tibolone, are estrogens). Tibolone and δ4-tibolone are thought to be responsible for the androgenic and progestogenic activity of tibolone, while 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for its estrogenic activity.
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