Cycrimine

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title: "Cycrimine" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["phenyl-compounds", "1-piperidinyl-compounds", "antiparkinsonian-agents", "cyclopentyl-compounds"] description: "Chemical compound" topic_path: "general/phenyl-compounds" source: "https://en.wikipedia.org/wiki/Cycrimine" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| IUPAC_name = 1-Cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol | image = Cycrimine.svg | image_class = skin-invert-image | width = | alt = | image2 = | width2 = | drug_name = | tradename = | licence_EU = | licence_US = Cycrimine | DailyMedID = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | dependency_liability = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 77-39-4 | CAS_supplemental = | ATCvet = | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | IUPHAR_ligand = | DrugBank = DB00942 | ChEBI_Ref = | ChEBI = 59692 | UNII_Ref = | UNII = 543567RFQQ | ChEMBL = 1201227 | synonyms = | PubChem = 2911 | ChemSpiderID = 2808 | StdInChI = 1S/C19H29NO/c21-19(18-11-5-6-12-18,17-9-3-1-4-10-17)13-16-20-14-7-2-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2 | StdInChIKey = SWRUZBWLEWHWRI-UHFFFAOYSA-N | chemical_formula = | C=19 | H=29 | N=1 | O=1 | SMILES = OC(CCN1CCCCC1)(C2CCCC2)c3ccccc3 | density = | melting_point = | melting_high = | melting_notes = | boiling_point = | boiling_notes = | solubility = | specific_rotation = | sec_combustion =

Cycrimine (trade name Pagitane) is a central anticholinergic drug designed to reduce the levels of acetylcholine in the treatment of Parkinson's disease. Its mechanism of action is to bind to the muscarinic acetylcholine receptor M1.

Synthesis

::figure[src="https://upload.wikimedia.org/wikipedia/commons/3/3d/Cycrimine_synthesis.png" caption="doi=10.1021/ja01164a127}}"] ::

References

References

1. (1979). "Psychotropic Drugs and Related Compounds". Pergamon Press.
2. (1950). "Antispasmodics. VII.¹ Additional Morpholinyl and Piperidyl Tertiary Alcohols". Journal of the American Chemical Society.

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::