Corbadrine

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title: "Corbadrine" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["alpha1-adrenergic-agonists", "alpha2-adrenergic-agonists", "beta-adrenergic-agonists", "beta-hydroxyamphetamines", "catecholamines", "decongestants", "human-drug-metabolites", "norepinephrine-releasing-agents", "vasoconstrictors"] description: "Chemical compound" topic_path: "general/alpha1-adrenergic-agonists" source: "https://en.wikipedia.org/wiki/Corbadrine" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| Verifiedfields = verified | verifiedrevid = 462091113 | IUPAC_name = 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol | image = Corbadrine.svg | image_class = skin-invert-image | width = 200px

| tradename = Neo-Cobefrine | pregnancy_category = | legal_status = Rx-only | routes_of_administration =

| bioavailability = | metabolism = | elimination_half-life = | excretion =

| CAS_number_Ref = | CAS_number = 829-74-3 | ATC_prefix = None | ATC_suffix = | PubChem = 164739 | IUPHAR_ligand = 508 | DrugBank_Ref = | DrugBank = DB06707 | ChemSpiderID_Ref = | ChemSpiderID = 144416 | UNII_Ref = | UNII = V008L6478D | KEGG_Ref = | KEGG = D02388 | ChEMBL_Ref = | ChEMBL = 677 | synonyms = Levonordefrin; α-Methylnorepinephrine; (–)-3,4-Dihydroxynorephedrine; 3,4,β-Trihydroxy-α-methylphenethylamine; 3,4,β-Trihydroxyamphetamine

| C=9 | H=13 | N=1 | O=3 | SMILES = Oc1ccc(cc1O)C@@HC@@HC | StdInChI_Ref = | StdInChI = 1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = GEFQWZLICWMTKF-CDUCUWFYSA-N

Corbadrine, sold under the brand name Neo-Cobefrine and also known as levonordefrin and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States. It is usually used in a pre-mixed solution with local anesthetics, such as mepivacaine.

The drug acts as a non-selective agonist of the α1-, α2-, and β-adrenergic receptors. It is said to have preferential activity at the α2-adrenergic receptor.

Corbadrine is also a metabolite of the antihypertensive drug methyldopa and plays a role in its pharmacology and effects.

Pharmacology

Pharmacokinetics

Corbadrine is metabolized primarily by catechol O-methyltransferase (COMT).

Chemistry

Corbadrine, also known as 3,4,β-trihydroxy-α-methylphenethylamine or as 3,4,β-trihydroxyamphetamine, as well as α-methylnorepinephrine or (–)-3,4-dihydroxynorephedrine, is a substituted phenethylamine and amphetamine derivative.

Analogues of corbadrine include α-methyldopamine, dioxifedrine (3,4-dihydroxyephedrine; α-methylepinephrine), dioxethedrin (3,4-dihydroxy-N-ethylnorephedrine; α-methyl-N-ethylnorepinephrine), and hydroxyamphetamine (4-hydroxyamphetamine; α-methyltyramine).

Society and culture

Names

Corbadrine is the generic name of the drug and its . It is also known as levonordefrin, which is its . Synonyms of corbadrine include α-methylnorepinephrine and (–)-3,4-dihydroxynorephedrine. The drug has been sold under the brand name Neo-Cobefrine.

References

References

1. Elks, J.. (2014). "The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies". Springer US.
2. (31 October 1999). "Concise Dictionary of Pharmacological Agents: Properties and Synonyms". Springer Science & Business Media.
3. (January 2000). "Index Nominum 2000: International Drug Directory". Taylor & Francis.
4. "DailyMed — Search results for levonordefrin".
5. Logothetis, D.D.. (2016). "Local Anesthesia for the Dental Hygienist". Elsevier Health Sciences.
6. Abraham, Donald J.. (15 January 2003). "Burger's Medicinal Chemistry and Drug Discovery". Wiley.
7. (October 2002). "Vasoconstrictors: indications and precautions". Dent Clin North Am.
8. (October 1963). "Studies on the Metabolism and Mechanism of Action of Methyldopa". Circulation.
9. "Levonordefrin".

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