Clopamide
Chemical compound
title: "Clopamide" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["piperidines", "sulfonamides", "hydrazides", "drugs-developed-by-novartis", "diuretics", "carbonic-anhydrase-inhibitors"] description: "Chemical compound" topic_path: "general/piperidines" source: "https://en.wikipedia.org/wiki/Clopamide" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Chemical compound ::
| Verifiedfields = changed | verifiedrevid = 447611902 | IUPAC_name = 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl- benzamide | image = Clopamide.svg | image_class = skin-invert-image | image2 = Clopamide ball-and-stick.png | image_class2 = bg-transparent
| tradename = Brinaldix | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_UK = | legal_US = | legal_status = | routes_of_administration =
| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =
| CAS_number_Ref = | CAS_number = 636-54-4 | ATC_prefix = C03 | ATC_suffix = BA03 | PubChem = 2804 | DrugBank_Ref = | DrugBank = | ChEMBL_Ref = | ChEMBL = 1361347 | ChemSpiderID_Ref = | ChemSpiderID = 2702 | UNII_Ref = | UNII = 17S83WON0I | KEGG_Ref = | KEGG = D02460
| C=14 | H=20 | Cl=1 | N=3 | O=3 | S=1 | smiles = O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N | StdInChI_Ref = | StdInChI = 1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21) | StdInChIKey_Ref = | StdInChIKey = LBXHRAWDUMTPSE-UHFFFAOYSA-N
Clopamide (trade name Brinaldix) is a piperidine diuretic.
Mechanism of action
Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.
References
References
- (September 1987). "Clopamide: plasma concentrations and diuretic effect in humans". Clinical Pharmacology and Therapeutics.
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