Charantin

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Chemical substance

title: "Charantin" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["phytosterols", "steroidal-glycosides", "saponins"] description: "Chemical substance" topic_path: "general/phytosterols" source: "https://en.wikipedia.org/wiki/Charantin" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical substance ::

Charantin is a chemical substance obtained from the Asian bitter melon (Momordica charantia), reputed to be responsible for the hypoglycaemic properties of those plants. It was identified by Lolitkar and Rao in 1960. It was also found in the similar African species M. foetida, by A. Olaniyi in 1975, under the name foetidin.{{Cite journal | last1 = Olaniyi | first1 = A. A. | title = A neutral constituent of Momordica foetida | journal = Lloydia | volume = 38 | issue = 4 | pages = 361–362 | year = 1975 | pmid = 1186439

Charantin is actually a 1:1 mixture of two steroidal saponins, β-sitosteryl glucoside () and 5,22-stigmasteryl glucoside (). It is a whitish crystalline substance, neutral and tasteless, melting at 266–268 °C. It is sparingly soluble in water

The name charantin has also been used by A. Parkash and other for a different compound, a peptide with molecular mass 9.7 kDa, also isolated from bitter melon seeds.{{Cite journal | last1 = Parkash | first1 = A. | last2 = Ng | first2 = T. B. | last3 = Tso | first3 = W. W. | title = Purification and characterization of charantin, a napin-like ribosome-inactivating peptide from bitter gourd (Momordica charantia) seeds | journal = The Journal of Peptide Research | volume = 59 | issue = 5 | pages = 197–202 | year = 2002 | doi = 10.1034/j.1399-3011.2002.00978.x | pmid = 11966976 | doi-access = free

References

References

  1. M. M. Lolitkar and M. R. Rajarama Rao. (1962). "Note on a Hypoglycaemic Principle Isolated from the fruits of Momordica charantia". Journal of the University of Bombay.
  2. (1996). "Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae)". Phytomedicine.
  3. (2007). "New approach for extraction of charantin from Momordica charantia with pressurized liquid extraction". Separation and Purification Technology.

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phytosterolssteroidal-glycosidessaponins