CFP-10
Protein made by Mycobacterium tuberculosis
title: "CFP-10" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["tuberculosis", "bacterial-proteins"] description: "Protein made by Mycobacterium tuberculosis" topic_path: "general/tuberculosis" source: "https://en.wikipedia.org/wiki/CFP-10" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Protein made by Mycobacterium tuberculosis ::
::data[format=table title="Infobox nonhuman protein"]
| Field | Value |
|---|---|
| Name | 10 kDa culture filtrate antigen CFP-10 |
| image | CFP-10.jpg |
| caption | Structure of the CFP10-ESAT6 complex from M. tuberculosis. |
| Organism | Mycobacterium tuberculosis |
| TaxID | 83332 |
| Symbol | esxB |
| EntrezGene | 886194 |
| PDB | 3FAV |
| RefSeqProtein | NP_218391 |
| UniProt | P0A566 |
| Chromosome | genome |
| EntrezChromosome | NC_000962.2 |
| GenLoc_start | 4352228 |
| GenLoc_end | 4352620 |
| :: |
| Name = 10 kDa culture filtrate antigen CFP-10 | image = CFP-10.jpg | width = | caption = Structure of the CFP10-ESAT6 complex from M. tuberculosis. | Organism = Mycobacterium tuberculosis | TaxID = 83332 | Symbol = esxB | AltSymbols = | IUPHAR_id = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | CAS_number = | CAS_supplemental = | DrugBank = | EntrezGene = 886194 | PDB = 3FAV | RefSeqmRNA = | RefSeqProtein = NP_218391 | UniProt = P0A566 | ECnumber = | Chromosome = genome | EntrezChromosome = NC_000962.2 | GenLoc_start = 4352228 | GenLoc_end = 4352620
CFP-10 within bacterial proteins (also known as ESAT-6-like protein esxB or secreted antigenic protein MTSA-10 or 10 kDa culture filtrate antigen CFP-10) is a protein that is encoded by the esxB gene.
CFP-10 is a 10 kDa secreted antigen from Mycobacterium tuberculosis. It forms a 1:1 heterodimeric complex with ESAT-6. Both genes are expressed from the RD1 region of the bacterial genome and play a key role in the virulence of the infection.
Function
10-kDa culture filtrate protein (CFP-10) is an antigen that contributes to the virulence of Mycobacterium tuberculosis. CFP-10 forms a tight 1:1 heterodimeric complex with 6kDaA early secreted antigen target (ESAT-6). In the mycobacterial cell, these two proteins are interdependent for their stability. The ESAT-6/CFP-10 complex is secreted by the ESX-1 secretion system, also known as the RD1 region. Mycobacterium tuberculosis uses this ESX-1 secretion system to deliver virulence factors into host macrophage and monocyte white blood cells during infection.
In Mycobacterium tuberculosis, the ESX-1 secretion system, a type VII bacterial secretion system, includes Rv3877 and two AAA ATPases, Rv3870 and Rv3871, the latter a cytosolic protein, as subunits. The ESAT-6/CFP-10 heterodimer complex is targeted for secretion by a C-terminal signal sequence on CFP-10 that is recognized by the cytosolic Rv3871 protein. Once ESAT-6/CFP-10 is next to the membrane of the host cell, the CFP-10 C-terminal attaches and binds itself to the cell surface. The ESAT-6/CFP-10 complex’s secretion and attachment to the host cell shows its contribution to the pathogenicity of Mycobacterium tuberculosis.
Structure
References
References
- (July 2005). "Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6". The EMBO Journal.
- "esxB ESAT-6-like protein EsxB [ ''Mycobacterium tuberculosis H37Rv'' ]". National Library of Medicine National Center for Biotechnology Information.
- (Apr 2006). "''Mycobacterium tuberculosis'' H37Rv ESAT-6–CFP-10 complex formation confers thermodynamic and biochemical stability". The FEBS Journal.
- (2009). "ESX-1 Secreted Virulence Factors Are Recognized by Multiple Cytosolic AAA ATPases in Pathogenic Mycobacteria". Molecular Microbiology.
- (October 2025}} a multi-transmembrane protein which may make up a pore that spans the inner membrane of the bacterium.{{cite thesis). "Characterization of the ESX-1 (SNM) secretion system in ''Mycobacteria''".
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