CDC27

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Protein-coding gene in humans

title: "CDC27" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in humans" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/CDC27" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in humans ::

Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.

Function

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis.

Interactions

CDC27 has been shown to interact with:

References

References

  1. (Nov 1993). "Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base". Proceedings of the National Academy of Sciences of the United States of America.
  2. "Entrez Gene: CDC27 cell division cycle 27 homolog (S. cerevisiae)".
  3. (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology.
  4. (Nov 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology.
  5. (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America.
  6. (Oct 2003). "The spindle checkpoint requires cyclin-dependent kinase activity". Genes & Development.
  7. (Sep 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell Biology.
  8. (Sep 1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proceedings of the National Academy of Sciences of the United States of America.
  9. (Dec 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nature Cell Biology.
  10. (Nov 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology.
  11. (Sep 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". The Biochemical Journal.
  12. (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes & Development.
  13. (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science.

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