CDC25C

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Protein-coding gene in humans

title: "CDC25C" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in humans" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/CDC25C" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in humans ::

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

Interactions

CDC25C has been shown to interact with MAPK14, CHEK1, PCNA, PIN1, PLK3 and NEDD4.

References

References

  1. (Feb 1991). "Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase". Science.
  2. "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)".
  3. Bulavin, D V. (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". [[Nature (journal).
  4. Sanchez, Y. (Sep 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". [[Science (journal).
  5. Kawabe, Takumi. (Mar 2002). "Cdc25C interacts with PCNA at G2/M transition". Oncogene.
  6. Shen, M. (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev..
  7. Goldstrohm, A C. (Nov 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol..
  8. Lu, P J. (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". [[Science (journal).
  9. Ouyang, B. (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene.

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