CD37

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Mammalian protein found in humans

title: "CD37" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["clusters-of-differentiation"] description: "Mammalian protein found in humans" topic_path: "general/clusters-of-differentiation" source: "https://en.wikipedia.org/wiki/CD37" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Mammalian protein found in humans ::

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility. CD37 expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms. CD37 controls both humoral and cellular immune responses. CD37-deficiency in mice leads to spontaneous development on B cell lymphoma, and patients with CD37-negative lymphomas have a worse clinical outcome.

References

References

  1. (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics.
  2. "Entrez Gene: CD37 CD37 molecule".
  3. (February 2005). "The tetraspanin web modulates immune-signalling complexes". Nature Reviews. Immunology.
  4. (May 2009). "Lateral organization of membrane proteins: tetraspanins spin their web". The Biochemical Journal.
  5. (October 2005). "Tetraspanin functions and associated microdomains". Nature Reviews Molecular Cell Biology.
  6. (2017-06-15). "Molecular interactions shaping the tetraspanin web". Biochemical Society Transactions.
  7. (March 2009). "The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity". PLOS Pathogens.
  8. (November 2012). "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival". Science Signaling.
  9. (August 2000). "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular and Cellular Biology.
  10. (March 2004). "A regulatory role for CD37 in T cell proliferation". Journal of Immunology.
  11. (January 2009). "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology.
  12. (February 2016). "Tetraspanin CD37 protects against the development of B cell lymphoma". The Journal of Clinical Investigation.
  13. (December 2016). "Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma". Blood.

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