CD120

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title: "CD120" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein family" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/CD120" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein family ::

::data[format=table title="infobox protein"]

Field	Value
Name	tumor necrosis factor receptor superfamily, member 1A
HGNCid	11916
Symbol	TNFRSF1A
AltSymbols	CD120a, TNFR1
EntrezGene	7132
OMIM	191190
RefSeq	NM_001065
UniProt	P19438
Chromosome	12
Arm	p
Band	13.2
::

| Name = tumor necrosis factor receptor superfamily, member 1A | caption = | image = | width = | HGNCid = 11916 | Symbol = TNFRSF1A | AltSymbols = CD120a, TNFR1 | EntrezGene = 7132 | OMIM = 191190 | RefSeq = NM_001065 | UniProt = P19438 | PDB = | ECnumber = | Chromosome = 12 | Arm = p | Band = 13.2 | LocusSupplementaryData = | Name = tumor necrosis factor receptor superfamily, member 1B | caption = | image = | width = | HGNCid =11917 | Symbol = TNFRSF1B | AltSymbols = CD120a, TNFR2 | EntrezGene = 7133 | OMIM = 191191 | RefSeq = NM_001066 | UniProt = P20333 | PDB = | ECnumber = | Chromosome = 1 | Arm = p | Band = 36.22 | LocusSupplementaryData = CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

• CD120a - TNFR1 - TNFR superfamily member 1A
• CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior, and is involved in neurotoxic processes. Elevated levels of TNFR1 has been found in severe mental disorders.

Signaling pathway

::figure[src="https://upload.wikimedia.org/wikipedia/commons/e/e4/TNF_signaling.jpg" caption="TNF]]-R1. Dashed grey lines represent multiple steps"] ::

References

References

1. (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell.
2. (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology.
3. (January 2009). "The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior". Psychopharmacology.
4. (2008). "TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease". J Neuroinflammation.
5. (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord.

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::