Carbogen

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title: "Carbogen" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["anxiogenics", "experimental-medical-treatments", "gases", "industrial-gases", "hallucinogens", "psychedelic-drug-research"] description: "Mixture of carbon dioxide and oxygen" topic_path: "general/anxiogenics" source: "https://en.wikipedia.org/wiki/Carbogen" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Mixture of carbon dioxide and oxygen ::

Carbogen, also called Meduna's Mixture after its inventor Ladislas Meduna, is a mixture of carbon dioxide and oxygen gas. Meduna's original formula was 30% CO2 and 70% oxygen, but the term carbogen can refer to any mixture of these two gases, from 1.5% to 50% CO2. It is a hallucinogen.

Mechanism

When carbogen is inhaled, the increased level of carbon dioxide causes a perception, both psychological and physiological, of suffocation because the brain interprets an increase in blood carbon dioxide as a decrease in oxygen level, which would generally be the case under natural circumstances. Inhalation of carbogen causes the body to react as if it were not receiving sufficient oxygen: breathing quickens and deepens, heart rate increases, and cells release alkaline buffering agents to remove carbonic acid from the bloodstream.

Psychotherapy

Carbogen was once used in psychology and psychedelic psychotherapy to determine whether a patient would react to an altered state of consciousness or to a sensation of loss of control.{{cite book | last = Markoff | first = John | author-link = John Markoff | title = What the Dormouse Said | publisher = Penguin | date = 2005 | pages = 25, 62 | isbn = 0-670-03382-0 | last = Walsh | first = Roger N. |author2=Charles S. Grob | title = Higher Wisdom: Eminent Elders Explore the Continuing Impact of Psychedelics | publisher = State University of New York Press | date = 2005 | pages =57–58; 98 | isbn = 0-7914-6517-9 }}

One subject reported: "After the second breath came an onrush of color, first a predominant sheet of beautiful rosy-red, following which came successive sheets of brilliant color and design, some geometric, some fanciful and graceful …. Then the colors separated; my soul drawing apart from the physical being, was drawn upward seemingly to leave the earth and to go upward where it reached a greater Spirit with Whom there was a communion, producing a remarkable, new relaxation and deep security."{{cite book | last = Meduna | first = Ladislas J. | title = Carbon Dioxide Therapy | publisher = Charles C. Thomas Publishing | date = 1950

Carbogen is rarely used in therapy anymore, largely due to the decline in psychedelic psychotherapy.

Uses

A carbogen mixture of 95% oxygen and 5% carbon dioxide can be used as part of the early treatment of central retinal artery occlusion. On this same premise it has also been proposed to be used in the management of sudden sensorineural hearing loss which can increase the blood flow to the inner ear and also possibly relieve the internal auditory artery spasm.

Carbogen is used in biology research to study in vivo oxygen and carbon dioxide flows, as well as to oxygenate the aCSF solution and stabilize the pH to about 7.4 in research on acute brain slices.

Its use with nicotinamide is also being investigated in conjunction with radiation therapy in the treatment strategy of certain cancers. Because increased tumor oxygenation improves the cell-killing effects of radiation, it is thought that the inhalation of these agents during radiation therapy could increase its effectiveness.

References

References

1. Prisman, Eitan. (2007). "Modified oxygen mask to induce target levels of hyperoxia and hypercarbia during radiotherapy: A more effective alternative to carbogen". International Journal of Radiation Biology.
2. [http://www.erowid.org/chemicals/carbogen/carbogen_basics.shtml Erowid Carbogen Vault: Basics].
3. Presti, David E.. (12 April 2017). "The Blackwell Companion to Consciousness". Wiley.
4. (June 2007). "Carbogen: An Introduction". Erowid Extracts.
5. Arnold JF, Kotas M, Fidler F, Pracht ED, Flentje M, Jakob PM. (2007). Quantitative regional oxygen transfer imaging of the human lung. ''Journal of Magnetic Resonance Imaging''. Aug 8;26(3):637-645
6. (6 May 2015). "A Multicentre, Randomised, Phase III Clinical Trial Comparing Accelerated Radiotherapy with Accelerated Radiotherapy Plus Carbogen and Nicotinamide (ARCON) in Clinical Stage T2-4 Laryngeal Carcinoma".

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