BRD7

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Protein-coding gene in the species Homo sapiens

title: "BRD7" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/BRD7" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.

Interactions

BRD7 has been shown to interact with IRF2 and HNRPUL1.

[[Azoospermia]]

BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced. Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.

References

References

  1. (November 1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett.
  2. (November 2008). "BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells". J Biol Chem.
  3. "Entrez Gene: BRD7 bromodomain containing 7".
  4. Staal, A. (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol..
  5. Kzhyshkowska, Julia. (April 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J..
  6. (2016). "Knockout of BRD7 results in impaired spermatogenesis and male infertility". Sci Rep.

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