Biodyl

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title: "Biodyl" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["drug-brand-names", "veterinary-drugs", "drug-safety"] topic_path: "general/drug-brand-names" source: "https://en.wikipedia.org/wiki/Biodyl" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

Biodyl is a trademark of Merial for a dietary supplement used in animals. It is manufactured in two formulations: a powder for use in an individual animal's drinking water, and an injectable solution. The injectable solution is available by veterinary prescription in some countries and over the counter in others.

Physical and chemical properties

Biodyl is formulated as a powder to be given in water, and as an injectable solution. The injectable solution is given under the skin, in the muscle, or in a vein, depending on the species of animal. Its intended uses include reducing physiological stress such as due to being transported, and preventing azoturia in performance animals. The manufacturer's own product information describes Biodyl as an "injection solution containing metabolic constituents (adenosine triphosphoric acid or ATP, magnesium aspartate, potassium aspartate, sodium selenite and vitamin B 12) for debility, convalescence and myopathies."{{cite web |url=http://ph.merial.com/swine/products.asp |publisher=Merial |title=Swine: Product Information |accessdate=April 22, 2009 |url-status=dead |archiveurl=https://web.archive.org/web/20080828104158/http://ph.merial.com/swine/products.asp |archivedate=August 28, 2008

Composition:{{cite web |url=http://www.mci-santeanimale.com/upload/produit/document/BIODYL.pdf |title=BIODYL |publisher=M.C.I. Santé Animale |accessdate=2009-04-22 |url-status=dead |archiveurl=https://web.archive.org/web/20100602001622/http://www.mci-santeanimale.com/upload/produit/document/BIODYL.pdf |archivedate=2010-06-02 |url=http://www.farmamondo.com/vista.cfm?ID=457&LI=e |title=Biodyl |url-status=dead |archiveurl=https://web.archive.org/web/20090430014050/http://www.farmamondo.com/vista.cfm?ID=457&LI=e |archivedate=2009-04-30

Legal status

In the United States, Biodyl is not FDA approved, "in that there is not in effect an approval of an application filed with respect to its intended use or uses".{{cite web |url=http://www.accessdata.fda.gov/scripts/ImportRefusals/ir_detail.cfm?EntryId=112-4397009-5&DocId=1&LineId=1&SfxId= |archive-url=https://web.archive.org/web/20121016085111/http://www.accessdata.fda.gov/scripts/ImportRefusals/ir_detail.cfm?EntryId=112-4397009-5&DocId=1&LineId=1&SfxId= |url-status=dead |archive-date=October 16, 2012 |title=Refusal Details as Recorded in OASIS by FDA for Refusal 112-4397009-5/1/1/ |publisher=Food and Drug Administration |accessdate=2009-06-14

Adverse effects

The manufacturer however, states that "Biodyl is safe when used as directed. It has been around from the 1950s and adverse reactions have been exceedingly rare over many years of tracking. Less than one animal in over 2 million doses."{{cite news |title=Scrutiny in horse deaths falls on vitamins |first=Craig |last=Johnson |publisher=CNN |url=http://edition.cnn.com/2009/US/04/22/polo.horses/ |date=April 22, 2009 |accessdate=April 22, 2009

Veterinary use

Implication in polo pony deaths

In April 2009, the sudden deaths of 21 polo ponies at Palm Beach International Polo Club in Florida were attributed by a polo team captain to error or tampering in the team's supply of Biodyl.{{cite news |url=http://www.lanacion.com.ar/nota.asp?nota_id=1120804 |title=Una historia que aún no despejó las dudas: Avanzan las investigaciones por la muerte de los equinos: en las próximas horas habría resultados |author= |publisher=La Nacion Deportiva |date=April 22, 2009 |accessdate=April 22, 2009 |language=Spanish |url=http://www.sun-sentinel.com/news/local/palmbeach/sfl-horses-dead-polo-wellington-palm-beach-041909,0,713717.story |title=Polo team captain: Vitamin likely killed 21 horses |author=Brian Haas, Missy Diaz |publisher=South Florida Sun-Sentinel |date=April 22, 2009 |accessdate=April 22, 2009 |url-status=dead |archiveurl=https://web.archive.org/web/20090421122440/http://www.sun-sentinel.com/news/local/palmbeach/sfl-horses-dead-polo-wellington-palm-beach-041909%2C0%2C713717.story |archivedate=April 21, 2009

In the United States, concerns about a possible manufacturing error or tampering were lost amid a media outcry about the "illegal" use of "illegal" drugs not approved by the FDA, even "banned" by the FDA.{{cite news |url=http://www.wpbf.com/news/19252623/detail.html |title=Banned Vitamin Supplement May Have Caused Horse Deaths Polo Team Member Tells Newspaper Horses Received French-Made Drug |publisher=West Palm Beach News |date=April 22, 2009 |accessdate=April 24, 2009 |url-status=dead |archiveurl=https://web.archive.org/web/20110718122123/http://www.wpbf.com/news/19252623/detail.html |archivedate=July 18, 2011 |title=Correction: Dead polo horses story |publisher=Associated Press via Google |url=https://www.google.com/hostednews/ap/article/ALeqM5h9-fMxZ9SYDFKaue53SVOuO0A5GwD97OCRV80 |date=April 23, 2009 |accessdate=April 24, 2009 |url=https://www.fda.gov/cvm/compliance.htm#FAQs |title=CVM and Compliance |publisher=U.S. FDA Center for Veterinary Medicine |date=March 26, 2008 |accessdate=April 24, 2009 |archiveurl=https://web.archive.org/web/20080115220442/https://www.fda.gov/cvm/compliance.htm#FAQs |archivedate=January 15, 2008}}

However, on April 23 a new concern emerged when a reputable pharmacy in Ocala, Florida disclosed that in compounding a preparation for the polo ponies which may have been intended to substitute for Biodyl, the pharmacy accidentally used an incorrect quantity of one of the ingredients.{{cite news |url=http://www.miamiherald.com/news/breaking-news/story/1014228.html |title=Pharmacy: We made mistake on supplement given to dead polo ponies |date=April 23, 2009 |author=Bill DiPaolo, Jane Musgrave |publisher=The Miami Herald |accessdate=April 23, 2009 |title=Sec. 608.400 - Compounding of Drugs for Use in Animals (CPG 7125.40) |journal=Compliance Policy Guidance |url=https://www.fda.gov/ora/compliance_ref/cpg/cpgvet/cpg608-400.html |publisher=U.S. Food and Drug Administration |date=July 8, 2003 |accessdate=April 24, 2009 |archiveurl=https://web.archive.org/web/20080115081805/https://www.fda.gov/ora/compliance_ref/cpg/cpgvet/cpg608-400.html |archivedate=January 15, 2008

References

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