BCL2L2

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Protein-coding gene in the species Homo sapiens

title: "BCL2L2" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/BCL2L2" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Bcl-2-like protein 2 is a 193-amino acid protein that in humans is encoded by the BCL2L2 gene on chromosome 14 (band q11.2-q12). It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w.

Function

This gene encodes a pro-survival (anti-apoptotic) member of the bcl-2 protein family, and is most similar to Bcl-xL. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.

Clinical significance

High levels of Bcl-w are seen in many cancers, including glioblastoma, colorectal cancer, non-small-cell lung carcinoma, and breast cancer. Breast cancer patients with metastasis have higher Bcl-w than breast cancer patients only having primary tumor. Elevated levels of Bcl-w has been shown to protect neurons from cell death induced by amyloid beta. Parkinson's disease patients with a mutant PARK2 gene have elevated Bcl-w. Bcl-w has been shown to contribute to cellular senescence.

Quercetin has been shown to inhibit the PI3K/AKT pathway leading to downregulation of Bcl-w.

Interactions

BCL2L2 has been shown to interact with:

References

References

  1. (October 1996). "bcl-w, a novel member of the bcl-2 family, promotes cell survival". Oncogene.
  2. "Entrez Gene: BCL2L2 BCL2-like 2".
  3. (2020). "BCL-w: apoptotic and non-apoptotic role in health and disease". Cell Death & Disease.
  4. (1996). "bcl-w, a novel member of the bcl-2 family, promotes cell survival.". Oncogene.
  5. (2020). "Toward Targeting Antiapoptotic MCL-1 for Cancer Therapy". Annual Review of Cancer Biology.
  6. (2019). "Targeting senescent cells in translational medicine". [[EMBO Molecular Medicine]].
  7. (September 1998). "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members". Mol. Endocrinol..
  8. (January 1998). "Bim: a novel member of the Bcl-2 family that promotes apoptosis". EMBO J..
  9. (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell.
  10. (October 2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis". Apoptosis.
  11. (June 1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members". Cell Death Differ..
  12. (July 2002). "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad". Eur. J. Immunol..

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