Allotopic expression

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Type of gene expression

title: "Allotopic expression" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["dna"] description: "Type of gene expression" topic_path: "general/dna" source: "https://en.wikipedia.org/wiki/Allotopic_expression" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Type of gene expression ::

References

  1. de Grey AD. (September 2000). "Mitochondrial gene therapy: an arena for the biomedical use of inteins". Trends Biotechnol..
  2. (October 2003). "Limitations of allotopic expression of mitochondrial genes in mammalian cells". Genetics.
  3. Perales-Clemente, Ester. (Jan 2011). "Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?". Nucleic Acids Res..
  4. (February 2016). "Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention". Cell Systems.
  5. (2019). "Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial". JAMA Ophthalmology.
  6. (27 December 2016). "Results from the Gensight Biologics Trial of ND4 Allotopic Expression".
  7. (2020). "Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy". Science Translational Medicine.
  8. "Gene Therapy Trial Successfully Improves Vision Mitochondrial gene therapy restores vision in landmark human trial".
  9. (10 December 2020). "Gene therapy injection in one eye surprises scientists by improving vision in both".
  10. [https://www.gensight-biologics.com/diseases-we-target/ Diseases We Target]
  11. (18 August 2016). "MitoSENS Project Results to be Published in the journal Nucleic Acids Research!". lifespan.io.
  12. "Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant". Oxford Journals.

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dna