AKAP10

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.

AKAP10 has been shown to interact with PDZK1 and PRKAR1A.

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• Human AKAP10 genome location and AKAP10 gene details page in the UCSC Genome Browser.

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