ADAMTS

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title: "ADAMTS" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["adamts", "ec-3.4.24", "protein-families"] description: "Family of protease enzymes" topic_path: "general/adamts" source: "https://en.wikipedia.org/wiki/ADAMTS" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Family of protease enzymes ::

ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. Nineteen members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.{{Cite journal | last1 = Kelwick | first1 = Richard | last2 = Desanlis | first2 = Ines | last3 = Wheeler | first3 = Grant N | last4 = Edwards | first4 = Dylan R | date = 2015-05-30 | title = The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family | journal = Genome Biology | language = En | volume = 16 | issue = 1 | pages = 113 | doi = 10.1186/s13059-015-0676-3 | pmc = 4448532 | pmid = 26025392 | doi-access = free

Like ADAMs, the name of the ADAMTS family refers to its disintegrin and metalloproteinase activity, and in the case of ADAMTS, the presence of a thrombospondin motif.

ADAMTS family members

::figure[src="https://upload.wikimedia.org/wikipedia/commons/a/a2/Clinical_findings_and_distribution_of_affected_organs_in_individuals_with_Mendelian_disorders_caused_by_pathogenic_mutations_in_different_ADAMTS_family_genes.jpg" caption="doi-access = free }}"] ::

• ADAMTS1 (or METH-1), an antiangiogenic
• ADAMTS2
• ADAMTS3
• ADAMTS4
• ADAMTS5 (=ADAMTS11)
• ADAMTS6
• ADAMTS7
• ADAMTS8 (or METH-2), an antiangiogenic
• ADAMTS9
• ADAMTS10
• ADAMTS12
• ADAMTS13
• ADAMTS14
• ADAMTS15
• ADAMTS16
• ADAMTS17
• ADAMTS18
• ADAMTS19
• ADAMTS20

References

References

1. Brocker, C. (Oct 2009). "Evolutionary divergence and functions of the ADAM and ADAMTS gene families.". Human Genomics.
2. (15 February 2005). "The ADAMTS metalloproteinases". Biochemical Journal.
3. Apte, Suneel. (2004). "A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family". The International Journal of Biochemistry & Cell Biology.
4. Cormier-Daire V, Le Goff C. (2011). "The ADAMTS(L) family and human genetic disorders". Human Molecular Genetics.
5. (March 2020). "Genomic Landscape and Mutational Spectrum of ADAMTS Family Genes in Mendelian Disorders Based on Gene Evidence Review for Variant Interpretation". Biomolecules.
6. [http://www.nature.com/bjc/journal/v91/n6/abs/6602107a.html METH-2 silencing and promoter hypermethylation in NSCLC]

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