Acetylleucine

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title: "Acetylleucine" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["alpha-amino-acids", "amino-acid-derivatives", "acetamides"] description: "Compound" topic_path: "general/alpha-amino-acids" source: "https://en.wikipedia.org/wiki/Acetylleucine" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Compound ::

| ImageFile = Acetylleucine.svg | ImageClass = skin-invert-image | ImageFile_Ref = | ImageSize = 160 | ImageName = Stereo, skeletal model of acetylleucine (S) | ImageCaption = (S)-(−)-N-Acetyl-leucine | IUPACName = 2-Acetamido-4-methylpentanoic acid | OtherNames = N-Acetylleucine; N-Acetyl-L-Leucine |Section1={{Chembox Identifiers | index_label = Racemic | index1_label = S (−) | index2_label = R (+) | CASNo = 99-15-0 | CASNo_Ref = | CASNo1 = 1188-21-2 | CASNo1_Ref = | CASNo2 = 19764-30-8 | CASNo2_Ref = | PubChem = 1995 | PubChem1 = 70912 | PubChem2 = 1241420 | ChemSpiderID = 1918 | ChemSpiderID_Ref = | ChemSpiderID1 = 64075 | ChemSpiderID1_Ref = | ChemSpiderID2 = 1042393 | ChemSpiderID2_Ref = | UNII = K76S41V71X | UNII_Ref = | UNII1_Ref = | UNII1 = E915HL7K2O | UNII2_Ref = | UNII2 = 91WU82GA22 | EINECS = 202-734-9 | KEGG = D07350 | KEGG_Ref = | MeSHName = acetylleucine | ChEBI = 17786 | ChEBI_Ref = | ChEMBL = 174357 | ChEMBL_Ref = | ChEMBL1 = 56021 | ChEMBL1_Ref = | Beilstein = 1724849 (S)-(−) | Gmelin = 985259 (S)-(−) | 3DMet = B00487 | SMILES = CC(C)CC(NC(C)=O)C(O)=O | StdInChI = 1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12) | StdInChI_Ref = | StdInChIKey = WXNXCEHXYPACJF-UHFFFAOYSA-N | StdInChIKey_Ref = |Section2={{Chembox Properties | C=8 | H=15 | N=1 | O=3 | Appearance = White crystals | MeltingPtK = 158 to 160 | LogP = −0.265 | pKa = 3.666 | pKb = 10.331 |Section8={{Chembox Related | OtherCompounds = ENU | Section6 = {{Chembox Pharmacology | Pharmacology_ref = | ATCCode_prefix = N07 | ATCCode_suffix = CA04 | ATC_Supplemental = | ATCvet = | Licence_EU = | INN = | INN_EMA = | Licence_US = | Legal_status = | Legal_AU = | Legal_AU_comment = | Legal_CA = | Legal_CA_comment = | Legal_NZ = | Legal_NZ_comment = | Legal_UK = | Legal_UK_comment = | Legal_US = | Legal_US_comment = | Legal_EU = | Legal_EU_comment = | Legal_UN = | Legal_UN_comment = | Pregnancy_category = | Pregnancy_AU = | Pregnancy_AU_comment = | Dependence_liability = | AdminRoutes = | Bioavail = | ProteinBound = | Metabolism = | Metabolites = | OnsetOfAction = | HalfLife = | DurationOfAction = | Excretion =

Acetylleucine (N-acetyl-leucine) is a modified leucine amino acid.

Two forms are commercialized: N-acetyl-DL-leucine (sold under the brand Tanganil, among others, and used in the treatment of vertigo) and N-acetyl-L-leucine (levacetylleucine, sold under the brand name Aqneursa, and used for the treatment of neurological manifestations of Niemann-Pick disease type C).

References

References

1. "N-Acetyl-DL-leucine".
2. (19 Dec 2016). "N07CA04 (acetylleucine)". Norwegian Institute of Public Health.
3. (2024-09-02). "Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports". Nature Communications.

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