ABL2

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Protein-coding gene in the species Homo sapiens

title: "ABL2" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["tyrosine-kinases", "oncogenes"] description: "Protein-coding gene in the species Homo sapiens" topic_path: "general/tyrosine-kinases" source: "https://en.wikipedia.org/wiki/ABL2" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Tyrosine-protein kinase ABL2 also known as** Abelson-related gene ** (Arg) is an enzyme that in humans is encoded by the ABL2 gene.

Function

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.

Interactions

ABL2 has been shown to interact with three proteins: Abl gene, catalase, and SORBS2. The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene. Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.

References

References

  1. (December 1986). "A novel human gene closely related to the abl proto-oncogene". Science.
  2. "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".
  3. (February 2017). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer.
  4. (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". The Journal of Biological Chemistry.
  5. (August 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". The Journal of Biological Chemistry.
  6. (July 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". The Journal of Biological Chemistry.
  7. (August 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science.
  8. (January 2004). "Diversity of structures and properties among catalases". Cellular and Molecular Life Sciences.
  9. (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research.

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tyrosine-kinasesoncogenes