2-Me-DET

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title: "2-Me-DET" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["2-alkyltryptamines", "n,n-dialkyltryptamines", "diethylamino-compounds", "psychedelic-tryptamines", "tihkal"] description: "Chemical compound" topic_path: "general/2-alkyltryptamines" source: "https://en.wikipedia.org/wiki/2-Me-DET" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

::data[format=table title="Infobox drug"]

Field	Value
image	2-Me-DET structure.svg
image_class	skin-invert-image
width	225px
image2	2-Me-DET 3D.png
image_class2	bg-transparent
width2	200px
routes_of_administration	Oral
class	Psychoactive drug; Serotonergic psychedelic; Hallucinogen
ATC_prefix	None
duration_of_action	6–8 hours
CAS_number	26628-88-6
UNII_Ref
UNII	SSF4F77CV3
PubChem	33561
ChemSpiderID	30962
synonyms	2-Methyl-DET; 2-Methyl-N,N-diethyltryptamine
IUPAC_name	N,N-diethyl-2-(2-methyl-1H-indol-3-yl)ethanamine
C	15
SMILES	CCN(CC)CCc1c(C)[nH]c2ccccc12
StdInChI	1S/C15H22N2/c1-4-17(5-2)11-10-13-12(3)16-15-9-7-6-8-14(13)15/h6-9,16H,4-5,10-11H2,1-3H3
StdInChIKey	VVUATPWGKMGHGM-UHFFFAOYSA-N
::

| drug_name = | image = 2-Me-DET structure.svg | image_class = skin-invert-image | width = 225px | image2 = 2-Me-DET 3D.png | image_class2 = bg-transparent | width2 = 200px

| pronounce = | tradename = | Drugs.com = | MedlinePlus = | licence_CA = | licence_EU = | DailyMedID = | licence_US = | pregnancy_AU = | pregnancy_category = | dependency_liability = | addiction_liability = | routes_of_administration = Oral | class = Psychoactive drug; Serotonergic psychedelic; Hallucinogen | ATC_prefix = None | ATC_suffix =

| legal_status =

| bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = 6–8 hours | excretion =

| CAS_number = 26628-88-6 | CAS_supplemental = | UNII_Ref = | UNII = SSF4F77CV3 | PubChem = 33561 | IUPHAR_ligand = | DrugBank = | ChemSpiderID = 30962 | KEGG = | ChEBI = | ChEMBL = | NIAID_ChemDB = | PDB_ligand = | synonyms = 2-Methyl-DET; 2-Methyl-N,N-diethyltryptamine

| IUPAC_name = N,N-diethyl-2-(2-methyl-1H-indol-3-yl)ethanamine | C=15 | H=22 | N=2 | SMILES = CCN(CC)CCc1c(C)[nH]c2ccccc12 | StdInChI = 1S/C15H22N2/c1-4-17(5-2)11-10-13-12(3)16-15-9-7-6-8-14(13)15/h6-9,16H,4-5,10-11H2,1-3H3 | StdInChIKey = VVUATPWGKMGHGM-UHFFFAOYSA-N

2-Me-DET, or 2-methyl-DET, also known as 2-methyl-N,N-diethyltryptamine, is a psychedelic drug of the tryptamine family. It is the 2-methyl derivative of diethyltryptamine (DET). The drug is taken orally.

Use and effects

In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin lists 2-Me-DET's dose as 80 to 120mg orally and its duration as 6 to 8hours. The effects of 2-Me-DET have been reported to include a vague unreal feeling, clouding and slowing of thoughts, DiPT-like sound distortion including higher pitches of music sounding muffled and tones shifting to a lower frequency, and stomach ache.

Interactions

Chemistry

Synthesis

The chemical synthesis of 2-Me-DET has been described.

Analogues

Analogues of 2-Me-DET include 2-methyltryptamine (2-MT; 2-Me-T), 2-methyl-DMT (2-Me-DMT; 2,N,N-TMT), 2-methyl-5-MeO-DMT (5-MeO-2,N,N-TMT), and 2-methyl-AMT (2-Me-AMT; 2,α-DMT).

History

2-Me-DET was first described in the scientific literature by R. B. Barlow and I. Khan in 1959. Subsequently, it was described in greater detail by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved).

References

References

1. {{CiteTiHKAL
2. (March 1959). "Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations". Br J Pharmacol Chemother.

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