2-Acetylpyridine

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title: "2-Acetylpyridine" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["2-pyridyl-compounds", "aromatic-ketones"] topic_path: "general/2-pyridyl-compounds" source: "https://en.wikipedia.org/wiki/2-Acetylpyridine" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

| verifiedrevid = | ImageFile = 2-Acetylpyridine.svg | ImageSize = 150px | PIN = 1-(Pyridin-2-yl)ethan-1-one | OtherNames = 1-(Pyridin-2-yl)ethanone 1-(2-Pyridinyl)ethanone Methyl 2-pyridyl ketone |Section1={{Chembox Identifiers | InChI = | InChIKey = | ChEMBL_Ref = | ChEMBL = | StdInChI_Ref = | StdInChI = | StdInChIKey_Ref = | StdInChIKey = | CASNo_Ref = | CASNo = 1122-62-9 | UNII_Ref = | UNII = 629O10UI3L | PubChem = 14286 | ChemSpiderID_Ref = | ChemSpiderID = 13648 | ChEBI_Ref = | ChEBI = | SMILES = CC(C1=NC=CC=C1)=O |Section2={{Chembox Properties | C=7 | H=7 | N=1 | O=1 | Appearance = | Density = 1.08 g/mL | MeltingPtC = 8 to 10 | MeltingPt_ref = | BoilingPtC = 188 to 189 | BoilingPt_ref = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPtC = 73 | FlashPt_ref = | AutoignitionPt =

2-Acetylpyridine is an organic compound with the formula . It is a viscous colorless liquid that is widely used as a flavoring substance. It is found in malt and produced by the Maillard reaction and by nixtamalization. It contributes to the flavor of corn tortillas, popcorn, and beer.

Synthesis

The compound is prepared by acylation of 2-bromopyridine via the Grignard reagent.

Chemical Use

References

References

  1. [http://www.sigmaaldrich.com/catalog/product/ALDRICH/W325104 Sigma Adrich]
  2. [http://www.chemicalbook.com/ChemicalProductProperty_US_CB7131206.aspx ChemicalBook]
  3. National Toxicology Program[https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/2-acetylpyridine_508.pdf "Summary of Data for Chemical Selection"]
  4. Trécourt, F.; Breton, G.; Bonnet, V.; Mongin, F.; Marsais, F.; Quéguiner, G., "New Syntheses of Substituted Pyridines via Bromine–Magnesium Exchange", Tetrahedron 2000, volume 56, pp. 1349-1360. {{doi. 10.1016/S0040-4020(00)00027-2.

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2-pyridyl-compoundsaromatic-ketones