1-Testosterone

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title: "1-Testosterone" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["abandoned-drugs", "secondary-alcohols", "androgens", "androstanes", "ketones"] description: "Chemical compound" topic_path: "arts/music" source: "https://en.wikipedia.org/wiki/1-Testosterone" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477208602 | IUPAC_name = (5S,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | image = 1-Testosterone.svg | image_class = skin-invert-image | width = 225px | image2 = 1-Testosterone molecule ball.png | image_class2 = bg-transparent | width2 = 225px

| tradename = | pregnancy_category = | legal_US = Schedule III | routes_of_administration = | class = Androgen; Anabolic steroid

| bioavailability = | protein_bound = | metabolism = Liver | elimination_half-life = | excretion = Urine

| CAS_number_Ref = | CAS_number = 65-06-5 | UNII_Ref = | UNII = Y984BV1Q0G | PubChem = 579094 | DrugBank_Ref = | DrugBank = DB01481 | ChemSpiderID_Ref = | ChemSpiderID = 206590 | ChEBI_Ref = | ChEBI = 59714 | synonyms = 1-Testo; 1-T; δ1-Dihydrotestosterone; δ1-DHT; Dihydroboldenone

| C=19 | H=28 | O=2 | SMILES = O=C4\C=C/[C@]1(C@@HC4)C | StdInChI_Ref = | StdInChI = 1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h7,9,12,14-17,21H,3-6,8,10-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = OKJCFMUGMSVJBG-ABEVXSGRSA-N

1-Testosterone (abbreviated and nicknamed as 1-Testo, 1-T), also known as δ1-dihydrotestosterone (δ1-DHT), as well as dihydroboldenone, is a synthetic anabolic–androgenic steroid (AAS) and a 5α-reduced derivative of boldenone (Δ1-testosterone). It differs from testosterone by having a 1(2)-double bond instead of a 4(5)-double bond in its A ring. It was legally sold online in the United States until 2005, when it was reclassified as a Schedule III drug.

Side effects

Pharmacology

Pharmacodynamics

A 2006 study determined that 1-testosterone has a high androgenic and anabolic potency even without being metabolized, so it can be characterized as a typical anabolic steroid. 1-Testosterone binds in a manner that is highly selective to the androgen receptor (AR) and has a high potency to stimulate AR-dependent transactivation. In vivo, an equimolar dose of 1-testosterone has the same potency to stimulate the growth of the prostate, the seminal vesicles and the androgen-sensitive levator ani muscle as the reference anabolic steroid testosterone propionate, but, unlike testosterone propionate, 1-testosterone also increases liver weight.

Chemistry

1-Testosterone, IUPAC name 17β-hydroxy-5α-androst-1-en-3-one, also known as 4,5α-dihydro-δ1-testosterone (Δ1-DHT) or as 5α-androst-1-en-17β-ol-3-one, is a synthetic androstane steroid and a derivative of dihydrotestosterone (DHT).

Derivatives

Two prohormones of 1-testosterone are 1-androstenediol and 1-androstenedione, the latter of which may be synthesized from stanolone acetate.

Detection in body fluids

Doping with 1-testosterone can be detected in urine samples using gas chromatography.

References

References

1. William Llewellyn. (2009). "Anabolics". Molecular Nutrition.
2. (August 2006). "17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties". Toxicol. Lett..
3. (December 2006). "An efficient synthesis of 5α-androst-1-ene-3,17-dione". Steroids.
4. S. Jain, A. Beotra and T. Kaur. (2005). "A Case Study: Detection of 1-Testosterone in Urine by GC-MSD". Recent Advances in Doping Analysis.

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::